Picoliter-to-Nanoliter Non-Contact
Microarray Printing
Protein Microarray & Multiplex Assay
Development
Printing
AssayImagingQuantitative
Analysis
From Single-Analyte Plate Assays to Microarray Multiplexing
NexaDroplet transforms repetitive microliter-scale plate workflows into nanoliter-scale arrayed bioassay workflows
Conventional Well-Based Single-Analyte Assay
- Single well, single analyte
- Labor- and time-intensive
- Complex workflow with serial processing
- High sample and reagent consumption
NexaDroplet Bio-Microarray Assay Technology
- Arrayed microdroplets for multiplex analysis
- High throughput, low manual labor
- Time & reagent efficient detection
- Compatible with automated scale-up
- Converts single-well, single-analyte assays into in-well microarray multiplex workflows.
- Integrates more assay sites in smaller areas to reduce consumption and improve throughput and consistency.
- Enables assay construction, imaging and analysis with higher information density.
Applications
Centered on protein microarrays, targeted proteomic testing, multiplex immunoassays and broader life-science research, NexaDroplet provides high-density, low-consumption, quantitative and application-ready microarray solutions.
[ AI Drug Discovery ][ Antibody Screening ][ High-Throughput Validation ]
NexaDroplet translates algorithm-generated candidates and condition sets into high-density microarray validation, enabling low-consumption parallel testing and hit prioritization.
[ IVD ][ Planar Multiplex Immunoassay ][ Protein Microarray ]
Multiple spatially separated assay sites can be arranged within a single well, supporting ELISA, chemiluminescent and fluorescent workflows for low-consumption multiplex detection.
[ Targeted Proteomics ][ Specific Binding ][ Biomarker Screening ]
NexaDroplet builds protein microarrays and interaction matrices on a single substrate, supporting high-throughput binding validation, specificity assessment and cross-reactivity screening.
[ Chamber-Based Digital PCR ][ Nucleic Acid Amplification ][ Micro-reaction Arrays ]
NexaDroplet stably constructs independent 200–500 nL microreaction chambers, supporting digital PCR, low-abundance nucleic acids, rare mutation detection and absolute quantification.
When candidate molecules, target hypotheses or condition combinations are rapidly generated by algorithms, the bottleneck often shifts to whether wet-lab validation can be performed in parallel at a sufficiently low cost.
NexaDroplet is well suited as a high-parallel validation platform after AI candidate generation. It can build dense condition matrices on a single substrate and use smaller reaction volumes to support hit prioritization, binding or activity prescreening, condition-space compression and comparable downstream analysis, helping model outputs enter real experimental feedback loops faster.
By arranging multiple spatially separated microdroplet reaction sites within a single well or on a single substrate, NexaDroplet can convert traditional single-analyte immunoassays into parallel multiplex detection workflows.
This format is suitable for panel development involving antigens, antibodies, cytokines, autoantibodies and other biomarkers. It can be compatible with mainstream assay chemistries such as ELISA-like, chemiluminescent and fluorescent readouts. While preserving assay readability and analytical interpretability, it enables multi-analyte detection in a single run, increases the information density of each sample and significantly reduces sample and reagent consumption.
Similar planar multiplex IVD approaches are already represented in the market by companies such as Meso Scale Diagnostics, Quansys and RayBio.
In proteomics and protein-interaction research, researchers often need to compare more molecular combinations, reaction conditions and recognition relationships within fewer experimental rounds. Conventional plate-based methods are limited by format, sample consumption and manual workflows, making systematic comparison difficult to scale.
NexaDroplet can construct high-information-density protein microarrays or interaction matrices on a single substrate. With smaller reaction volumes, it can accommodate more candidate molecules, reaction conditions and control relationships. Combined with unified imaging and analysis workflows, it supports binding validation, competition analysis, specificity assessment, cross-reactivity screening and assay optimization.
This provides a higher-throughput, lower-consumption and more standardized experimental foundation for proteomics research, antibody discovery and related product development.
By constructing large numbers of independent, volume-controlled microreaction chambers on a single substrate, chamber-based nucleic acid amplification systems, such as chamber-based digital PCR and microwell array PCR, can achieve higher reaction parallelism and stronger compartmentalization at smaller volumes.
NexaDroplet is suitable for the front-end construction of these systems. It enables stable, uniform and low-error dispensing and arrayed layout of 200–500 nL reaction units. This reduces sample and reagent consumption while improving reaction consistency and chamber utilization.
This capability can support workflow development for low-abundance nucleic acid detection, rare mutation identification, absolute quantification and high-sensitivity molecular testing, and can help form more standardized and reproducible miniaturized nucleic acid detection systems.
NexaDroplet:
A Closed-Loop System from Droplet
Generation to Result Analysis
Connecting spotting, assay workflow, readout and analysis into an executable, readable and reproducible experimental workflow.
Droplet Generation
NP-series spotters convert liquid samples into stable, precise and controllable microdroplets and ordered arrays.
Application Workflow
NexaSpot® application services translate spotting parameters, surface treatment, reaction conditions and QC rules into executable assay workflows.
Signal Readout
NexaScanner® readers standardize microarray signal acquisition and provide consistent input for recognition, quantification and interpretation.
Intelligent Analysis
NexaAnalyzer® software performs automated recognition, quantification, quality control and result output, forming a structured data loop.
The Core Technology of NexaDroplet®：
A Microdroplet Spotting Route Built for Biological Microarrays
Built on pulsed pneumatic microdroplet generation, NexaDroplet® enables gentle, stable and low-residue spotting for biological reagents, while supporting high-speed reagent switching and high-throughput microarray construction.
Non-Contact Picolitre-scale Microdroplet Generation
Instead of piezoelectric or thermal inkjet actuation, NexaDroplet controls droplet formation through transient pneumatic pulses and fluidic response, enabling gentler spotting of proteins, antibodies and enzymes.
High-Speed Multi-Reagent Switching
Designed for multi-target, multi-antibody, multi-concentration and multi-condition workflows, NexaDroplet enables rapid reagent switching and continuous spotting to improve the efficiency of complex microarray construction.
Low Residue and Carryover Control
Through low-dead-volume fluidics, washing validation and residue control, NexaDroplet reduces carryover risk between different reagents and is suitable for continuous multi-analyte and multi-condition spotting workflows.
Bio-Reagent-Friendly Spotting System
Optimized for proteins, antibodies, enzymes, cytokines and other biological reagents, the system balances droplet formation, deposition and surface reaction conditions to support reagent activity, spot stability and multiplex assay compatibility.
400 pL–500 nL
Controlled Spotting Volume
100 μm–1 mm
Controlled Spot Diameter
>200 Reagents/hour
Multi-Reagent Switching Capacity
CV < 3%
Spotting Volume Uniformity
Residual Volume <20 nL
Low-Residue Fluidic Control
No Detectable Carryover
Under Validated Conditions
Product Portfolio
Advanced instruments, software and application modules supporting the complete microdroplet workflow.
NP-Lite
Pioneering Handheld Picoliter-Scale Microdroplet Spotter
A lightweight entry point for microdroplet experiments, suitable for early-stage validation, method exploration and rapid feasibility testing.
NP-Lab
Benchtop Automated Microdroplet Spotting Workstation
Balancing flexibility and automation, NP-Lab is designed for assay optimization, parameter screening and small-batch production.
NP-Med
Ultra-High-Throughput Customized Workstation for Scaled Production
NP-Med is built for customized batch production, combining automated operation and strict quality control for scalable microarray manufacturing.
NexaScanner
Optical Readout System Designed for Microarrays
Rapidly captures high-density microspot results and provides standardized input for downstream recognition and quantitative analysis.
NexaAnalyzer
Intelligent Analysis Software for Microarray Data
Automatically performs recognition, quantification, quality control and result output, forming a structured data workflow.
NexaSpot
Application Modules That Bring Microdroplet Capabilities into Real-World Assays
Supports method transfer, process adaptation and application-specific development, connecting experimental goals with platform capabilities.
NexaDroplet® 3E Core Advantages
NexaDroplet® integrates microdroplet spotting, bioassay workflow development, signal readout and intelligent analysis into one unified workflow, helping customers achieve higher-quality experiments at lower cost and translate validated methods into reproducible, scalable applications.
Economy · Lower Cost
NexaDroplet® reduces conventional microliter-scale assay consumption to picoliter-to-nanoliter microdroplet units, significantly lowering the use of samples, antigens, antibodies, enzymes, substrates and buffers.
High-density microdroplet arrays enable multiple targets, conditions or candidate molecules to be tested on the same substrate, reducing repeated plates, manual transfers, batch loss and trial-and-error cost during assay development.
Excellence · Higher Performance
NexaDroplet® improves assay performance through the coordinated integration of spotting, workflow development, readout and analysis.
Its non-contact pneumatic spotting enables stable droplet generation, precise deposition and consistent spot formation. Combined with surface treatment, reaction optimization, optical imaging and intelligent analysis, the platform supports spot recognition, signal quantification, background correction and quality control.
The result is not simply smaller droplets, but more stable, repeatable and comparable assay data.
Execution · Faster Translation
NexaDroplet® is designed not only to complete individual experiments, but to help customers turn assay concepts into executable, repeatable and deliverable workflows.
The platform supports method validation, condition screening, parameter optimization, process standardization, QC rule development, automated operation and batch-oriented delivery. For IVD, protein microarrays, CRO/CDMO services and high-throughput screening customers, this means faster transition from R&D verification to application validation and production-ready workflows.
Partner With Us to Build the Future of Bioassay Infrastructure
From multiplex testing and high-throughput screening to microdroplet spotting and AI-assisted analysis, NexaLab is building experimental infrastructure for the next generation of life science R&D. We welcome investors and industry partners to join us in accelerating productization, commercialization and scalable deployment.